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About

Advanced (metastatic) breast cancer means that the cancer has spread to other parts of the body. Doctors often use one chemotherapy drug to treat advanced breast cancer because it causes fewer side effects than a combination of drugs. For advanced breast cancer chemo can be used as the main treatment for women whose cancer has spread outside the breast and underarm area, either when it is diagnosed or after initial treatments. The length of treatment depends on how well the chemo is working and how well you tolerate it. Women with stage iv breast cancer are most often treated with systemic therapy. This may include hormone therapy, chemotherapy, targeted therapy, or some combination of these. Local treatments such as surgery or radiation might sometimes be used to help prevent or treat symptoms. Find out about chemotherapy for advanced breast cancer, including how you have it and the drugs that might be used. Breast cancer targeted therapy is commonly paired with other treatments, such as chemotherapy, to help control cancer that has spread or to prevent breast cancer recurrence. Immunotherapy drugs known as checkpoint inhibitors may be an option to treat patients with breast cancers whose cells have specific genetic features. Neoadjuvant (preoperative) chemotherapy is used in locally advanced breast cancer patient with the goal of shrinking the primary tumor to enable mastectomy or breast-conserving surgery. A complete pathological response (complete or very nearly complete lack of tumor cells at resection) is the only outcome that has been shown to correlate with disease-free survival. The first prospective study for nct in locally advanced, inoperable breast cancer is dated in 1973, by the european institute of oncology and the primary purpose was to downstage the primary tumor in order to achieve surgical resection. Many other trials followed in the past two decades studying the role of induction chemotherapy.

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